【2020.11.10】Potential intestinal infection and fecal-oral transmission of SARS-CoV-2

Publisher:陶万银Release time:2020-12-01Browse times:375

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has spread to >200 countries and regions, infecting >40,000,000 people by October 30th, 2020. SARS-CoV-2 is thought to spread mainly through respiratory droplets and close contact. However, recent reports have shown that a significant proportion of coronavirus disease 2019 (COVID-19) patients develop gastrointestinal symptoms, and nearly half of the confirmed COVID-19 patients have shown detectable SARS-CoV-2 RNA in their fecal samples. Moreover, SARS-CoV-2 infection reportedly alters intestinal microbiota, which is correlated with the expression of inflammatory factors. Furthermore, multiple in vitro and in vivo animal studies have provided direct evidence of intestinal infection by SARS-CoV-2. These lines of evidence highlight the SARS-CoV-2 gastrointestinal infection and potential fecal–oral transmission. Here, we summarize current findings on the gastrointestinal manifestations of COVID-19 patients and its possible mechanisms. We also discuss how SARS-CoV-2 gastrointestinal infection may occur as well as the current evidence, and future studies needed to establish the occurrence of fecal–oral transmission by this virus.