Recently, the National Natural Science Foundation of China has determined the 2023 Youth Students Basic Research Projects (Ph.D. Students) funding list, and Lab of Intestinal lmmune and Microbiota was approved 1. Ph.D. student Tingting Wan at class of 2021 is responsible for the approved project Investigate the response pattern of food antigens in small intestine.
Project Leader: Tingting Wan
Ph.D. candidate, class of 2021, USTC
Because of the increasing prevalence of food allergic cases in recent years, while the knowledge of food allergy and food tolerance in the field which focused on dendritic cells and is still limited, we decided to do something. Our previous study pointed out that the MHCII levels of small intestinal epithelial cells upregulated by food antigens can induce tolerance (Cell, 2023), so we’d like to further explore the specific mechanism how small intestinal epithelial cells recognize food antigenic peptides to maintain tolerance. And our ultimate goal is to elucidate the pattern of different antigen-presenting cells in intestine responding to food antigens.
Tingting Wan, a Ph.D. student majors in basic immunology at 2021’s class, University of Science and Technology of China, is supervised by Professor Shu Zhu. During her graduate training stage, she mainly researches in mucosal innate immune recognition and immune tolerance, and currently published papers in Protein & Cell and Cell as first author and co-first author.
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