We are using various mouse models to study intestinal immune responses toward environmental cues including microbes and food.

We demonstrated how dsRNA from enteric viruses (norovirus, rotavirus, and commensal viruses) are recognized by intestinal epithelial cells-specific Nod-like recpetors-Nlrp6 and Nlrp9, and activate inflammasome and interferon (Cell, 2021; Nature, 2017a; Science, 2016); and also sensed by DC-expressed Rig-I to sustain the expansion of intraepithelial lymphocytes (Nature Immunology, 2019).

Our recent work elucidated that the dietary-antigen-dependent cleavage of Gasdermin D maintains food toleranceirrespective of pyroptosis (Cell, 2023).

We have developed strategies (glucosylated nanoparticle encapsulated antibiotics or vitamin supplementation) to intervene microbiota dysbiosis and associated diseases such as IBD(Nature Biomedical Engineering, 2022; Cell Reports, 2022).